Pragmatic randomised trials using routine electronic health records: putting them to the test
نویسندگان
چکیده
Tjeerd-Pieter van Staa head of research and honorary professor of epidemiology 1 2 , Ben Goldacre research fellow , Martin Gulliford professor of public health , Jackie Cassell professor of primary care epidemiology , Munir Pirmohamed NHS chair of pharmacogenetics , Adel Taweel senior lecturer in software engineering , Brendan Delaney Guy’s and St Thomas’ charity chair in primary care research , Liam Smeeth professor of clinical epidemiology 3
منابع مشابه
The Salford Lung Study protocol: a pragmatic, randomised phase III real-world effectiveness trial in asthma
BACKGROUND Novel therapies need to be evaluated in normal clinical practice to allow a true representation of the treatment effectiveness in real-world settings. METHODS/DESIGN The Salford Lung Study is a pragmatic randomised controlled trial in adult asthma, evaluating the clinical effectiveness and safety of once-daily fluticasone furoate (100 μg or 200 μg)/vilanterol 25 μg in a novel dry-p...
متن کاملUse of electronic health records in the design and evaluation of implementation research in primary care - experiences from the aspire cluster randomised controlled trials (CRCTS)
The use of routine datasets in the evaluation of interventions in clinical trials is increasing. Action to Support Practices Implementing Research Evidence (ASPIRE) is an NIHR Programme aiming to develop and test ways to support general practices in implementing key NICE recommendations. Multifaceted intervention packages have been developed to target four key clinical practice recommendations,...
متن کاملMonitoring safety in a phase III real‐world effectiveness trial: use of novel methodology in the Salford Lung Study
BACKGROUND The Salford Lung Study (SLS) programme, encompassing two phase III pragmatic randomised controlled trials, was designed to generate evidence on the effectiveness of a once-daily treatment for asthma and chronic obstructive pulmonary disease in routine primary care using electronic health records. OBJECTIVE The objective of this study was to describe and discuss the safety monitorin...
متن کاملPragmatic clinical trials embedded in healthcare systems: generalizable lessons from the NIH Collaboratory
BACKGROUND The clinical research enterprise is not producing the evidence decision makers arguably need in a timely and cost effective manner; research currently involves the use of labor-intensive parallel systems that are separate from clinical care. The emergence of pragmatic clinical trials (PCTs) poses a possible solution: these large-scale trials are embedded within routine clinical care ...
متن کاملText messaging reminders for influenza vaccine in primary care: protocol for a cluster randomised controlled trial (TXT4FLUJAB)
INTRODUCTION The UK government recommends that at least 75% of people aged under 64 with certain conditions receive an annual influenza vaccination. Primary care practices often fall short of this target and strategies to increase vaccine uptake are required. Text messaging reminders are already used in 30% of practices to remind patients about vaccination, but there has been no trial addressin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 344 شماره
صفحات -
تاریخ انتشار 2012